A rocket was fired from Egypt’s Sinai region on Monday and it hit the Eshkol region in Israel, officials have said.
The incident came only hours before the start of the week-long Jewish Passover holiday at sundown.
No injuries or major damage have been reported, an army statement said.
Earlier in the day, Israel had taken the rare step of closing a major border crossing into Egypt, citing increased security threats.
Israelis holidaying in the Sinai would be allowed to return but those seeking to enter through the Taba crossing would not be permitted for the next week, a statement from the prime minister’s office said.
Israel had already on Sunday updated its warning against travel to Sinai, citing Islamist bomb attacks on Egyptian churches the same day that killed 44 people.
In February, a volley of rockets was fired from the fractious Sinai region into Israel, with the Islamic State affiliate in the Sinai claiming responsibility.
It was the first time since 2015 that rockets had been fired at Israel from Egypt.
IS has been waging a deadly insurgency against Egyptian security forces in the Sinai but it has rarely attempted attacks against Israel.
Egypt and Jordan are the only Arab countries that have signed a peace treaty with the Jewish state.